Plasmodium falciparum- and merozoite surface protein 1-specific antibody isotype balance in immune Senegalese adults.

نویسندگان

  • C M Nguer
  • T O Diallo
  • A Diouf
  • A Tall
  • A Dieye
  • R Perraut
  • O Garraud
چکیده

This study shows markedly different isotype distributions of antibodies to asexual blood stages of Plasmodium falciparum and to merozoite surface protein 1 in clinically immune Senegalese adults depending on the study site. The relationships between immunoglobulin M (IgM) and IgG and between IgG3 and IgG1 antibodies differed in settings where transmission is perennial compared to settings where it is seasonal. This suggests a role for antibody class and/or subclass production and utilization in the regulation of protective immunity to such antigens.

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عنوان ژورنال:
  • Infection and immunity

دوره 65 11  شماره 

صفحات  -

تاریخ انتشار 1997